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The Pulikkan Lab at the Versiti Blood Research Institute, Medical College of Wisconsin studies transcriptional and epigenetic regulation in normal and malignant hematopoietic stem cell differentiation. In particular, our lab is investigating how mutations in transcription factors such as core-binding factors (CBFs) and C/EBPα lead to development of acute myeloid leukemia (AML). Our lab applies genetic, epigenetic and biochemical approaches in genetically modified mouse models, humanized mouse models and human primary leukemic cells to identify regulatory pathways that are deregulated in AML. Our goal is to identify and characterize novel therapeutic targets, and translate them to the clinic with academic and pharmaceutical collaborations. We hope that our discoveries will lead to better therapeutic strategies for patients with leukemia.
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