Publications

Key Research Papers

 

Pulikkan JA, Hegde M, Ahmed H, Belaghzal H, Illendula A, Yu J, O’Hagen K, Ou J, Muller-Tidow C, Wolfe SA, Zhu LJ, Dekker J, Bushweller JH, Castilla LH. CBFβ-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia. Cell 2018 Jun 28;174(1):172-186.

     Comment in: Cancer Discovery 2018 Aug 8(8): 913

                          Stem Cell Investigation 2018;5:30 (Editorial)

 

Illendula A*, Pulikkan JA*, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH¶, Bushweller JH¶. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science 2015 Feb 13;347(6223):779-84.

(*Co-first author)   (¶ Corresponding author).

     Comment in:  Science. 2015 Feb 13; 347(6223):713-4;

                           Nature Chemical Biology. 2015 Mar 18;11(4):241

 

Pulikkan JA*, Madera D*, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH. Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood 2012 Jul 26;120(4):868-79.

     Comment in:  Blood 2012 Jul 26;120(4):703-4.

Pulikkan JA and Castilla LH. Pre-leukemia in inv(16) acute myeloid leukemia development. Frontiers in Oncology 2018 Apr  26: 8(129): 1-7. [Invited Review]

Pulikkan JA¶, Tenen DG¶, Behre G¶. C/EBPα deregulation as a paradigm for leukemogenesis. Leukemia 2017 Nov;31(11):2279-2285. [Invited Review] (¶ Corresponding author)

Pulikkan JA, Peramangalam PS, Dengler V, Müller-Tidow C, Bohlander SK, Preudhomme C, Tenen DG, Behre G. C/EBPα regulated microRNA-34a targets E2F3 during granulopoiesis and is downregulated in AML with CEBPA mutations. Blood 2010 Dec 16;116(25):5638-49.

 

Pulikkan JA, Dengler V, Peer Zada AA, Kawasaki A, Geletu MH, Pasalic Z, Bohlander SK, Ryo A, Tenen DG, Behre G. Elevated PIN1 expression by C/EBPα-p30 blocks C/EBPα induced granulocytic differentiation via c-Jun in AML. Leukemia 2010 May;24(5):914-23.

 

Pulikkan JA*, Dengler  V*, Peramangalam PS, Peer Zada AA, Müller-Tidow C, Bohlander SK, Tenen DG, Behre G. Cell cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood 2010 Mar 4;115(9):1768-78.

 

Other Research Papers

 

Pulikkan JA, Madera D, Illendula A, Zhu LJ, Bushweller JH, Castilla LH. The microRNAs miR-17/20a mediate inv(16) acute myeloid leukemia initiation and maintenance (submitted).

Choi A, Illendula A, Pullikkan JA, Roderick JE, Tesell JT, Yu J, Hermance N, Zhu L, Castilla LH,  Bushweller JH and Kelliher MA. RUNX1 is required for oncogenic Myb and Myc enhancer activity in T cell acute lymphoblastic leukemia. Blood 2017 Oct 12;130(15):1722-1733.

 

Illendula A, Gilmour J, Grembecka J, Tirumala VS, Boulton A, Schmidt C, Wang L,  Pullikan JA, Zong H, Kuscu C, Pickin A, Zhou Y, Gao Y, Dixon L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-31.

 

Xue L, Pulikkan JA, Valk PJ, Castilla LH. NrasG12Doncoprotein inhibits apoptosis of pre-leukemic cells expressing CBFb-SMMHC via activation of MEK/ERK axis in mice. Blood 2014 Jul 17;124(3):426-36.

 

Geletu MH, Balkhi MY, Peer Zada AA, Christopeit M, Pulikkan JA, Trivedi AK, Tenen DG, Behre G. Target proteins od C/EBPalphap30 in AML: C/EBPα-p30enhances sumoylation of C/EBPalphap42 via up-regulation of Ubc9. Blood 2007, Nov 1; 110(9):3301-9.

 

Zada AA, Pulikkan JA, Bararia D, Geletu M, Trivedi AK,  Balkhi MY,  Hiddemann  WD, Tenen  DG, Behre HM, Behre G. Proteomic discovery of Max as a novel interacting partner of  C/EBPα: a  Myc/Max/Mad link. Leukemia 2006, 20(12):  2137-2146.

 

Peer Zada AA*, Geletu MH*, Pulikkan JA*, Müller-Tidow CT, Hiddemann WD,  Tenen DG, Behre G. Proteomic Analysis of Acute Promyelocytic Leukemia: PML-RARalpha Leads to Decreased phosphorylation of OP18 at Serine 63. Proteomics 2006, 6(21) 5705-5719.

 

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